adv.绝望地；无望的；无可救药的

He reached out hopelessly, like a drowning man grabbing at sticks and straws. 他绝望地向外探摸着，就像一个溺水的人在抓取稻草和树枝似的。

The self-style decadent insists on lying down in the belief that he is hopelessly paralyzed. 那自称为颓废派者，由于深信自己已毫无希望地全身麻痹而坚持要躺下来。

By this time, he was hopelessly pickled. 到这时他已经烂醉如泥了。

He's hopelessly inefficient, but I suppose he means well. 他低能得无以复加,然而却是出于好心。